Why Do Some Celiacs Tolerate Oats While Others Don’t?
Oct 31 2008

Why Do Some Celiacs Tolerate Oats While Others Don’t?

Have you ever noticed some Celiacs can have oats while others can’t without having painful Celiac symptoms?   There is a reason for this, at least according to a recent study which looked at the molecular basis for oats intolerance in people with Celiac Disease

Because this is one of those really common questions, I figured it couldn’t hurt to share this information with our readers.   Here is the study and the results:

Methods and Findings

We selected for study nine adults with celiac disease who had a history of oats exposure. Four of the patients had clinical symptoms on an oats-containing diet, and three of these four patients had intestinal inflammation typical of celiac disease at the time of oats exposure. We established oats-avenin-specific and -reactive intestinal T-cell lines from these three patients, as well as from two other patients who appeared to tolerate oats. The avenin-reactive T-cell lines recognized avenin peptides in the context of HLA-DQ2. These peptides have sequences rich in proline and glutamine residues closely resembling wheat gluten epitopes. Deamidation (glutamine?glutamic acid conversion) by tissue transglutaminase was involved in the avenin epitope formation.

Conclusions

We conclude that some celiac disease patients have avenin-reactive mucosal T-cells that can cause mucosal inflammation. Oat intolerance may be a reason for villous atrophy and inflammation in patients with celiac disease who are eating oats but otherwise are adhering to a strict gluten-free diet. Clinical follow-up of celiac disease patients eating oats is advisable.

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Article Written by: Kyle Eslick

Kyle is the founder and webmaster of Celiac-Disease.com, as well as the creator of the popular Celiac Support Groups directory.

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